I do that, otherwise I wouldn't have been able to launch games. I don't even have a north american account.
Outfox sets the game server to los angeles when I enter a game on eu west, and sets the game server to ireland when I enter a game on eu nordic, in both cases I failed to connect to the games. (after champion select is over.)
I can connect to games normally with outfox off, but I want to try if outfox could help with reducing my ping, but this isn't helping. : P